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Which material in a metal frame is most likely to cause allergic reactions?

Titanium

Aluminum

Plastic

Nickel

Plastic is generally hypoallergenic, so option C is not the most likely cause of allergic reactions within a metal frame.

Both titanium and aluminum are considered bio-compatible and are often used in medical implants, making them unlikely to cause allergic reactions.

On the other hand, nickel is a common allergen and is often found in metal frames, making it the most likely material to cause allergic reactions among the given options.

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